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The vast number of preclinical studies on NAD + modulation via precursors or modulators of NADase enzymes has established a tight functional relationship between NAD + metabolism and mitochondrial homeostasis

Carnitine is synthesized in the liver and kidneys and is transported to areas where it is needed

As the activation of both JNK and caspase-3 contributed to TNF-induced cell death with NF-B inhibition, we examined the effects of HFD consumption on the hepatic activation status of JNK and caspase-3 cleavage

In addition, we explored the crosstalk between macrophages and endothelial cells using in vitro co-cultures

Highly palatable food during adolescence improves anxiety-like behaviors and hypothalamic-pituitary-adrenal axis dysfunction in rats that experienced neonatal maternal separation